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Senior Automation Engineer, Laboratory Automation – Analytical Sciences

Astrazeneca

Santa Monica, CA · Posted October 16, 2026

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About the job

We are seeking an accomplished Senior Automation Engineer to join the Laboratory Automation team within Analytical Sciences. This fully on-site role is based in Santa Monica, California. Reporting to the Associate Director of Laboratory Automation, you will develop, implement, and optimize automation solutions for cell-based, immunological, and genomic assays. You will own deliverables, maintain momentum, and proactively communicate progress, risks, decisions, and resource needs. The role combines hands-on engineering with project execution and stakeholder management to improve assay robustness, workflow efficiency, and data quality for novel engineered cell therapy products.

Key Responsibilities

Design, build, and implement automation solutions for cell-based, immunological, and genomic assays

Program, test, and maintain Hamilton VANTAGE and other automated liquid-handling workstations

Develop and optimize liquid-handling scripts for complex bioassay workflows

Partner with scientists, engineers, and IT specialists to translate manual processes into robust automated workflows

Troubleshoot, maintain, and continuously improve automated systems to ensure reliable performance

Support the transfer of automated assay methods to Quality Control teams and external partners

Create and maintain SOPs, user guides, and technical reports

Train laboratory personnel on automation systems, workflows, and best practices

Evaluate emerging automation technologies and recommend opportunities for implementation

Qualifications

Bachelor’s or master’s degree in bioengineering, biotechnology, mechanical engineering, electrical engineering, or a related field of hands-on experience with laboratory automation systems

Advanced expertise with Hamilton liquid-handling platforms and VENUS software

Experience developing integrated automation workflows using scheduling software such as HighRes Cellario

Proficiency in Python, C++, or a similar programming language

Experience with cell culture, immunological assays, and flow cytometry

Knowledge of GMP requirements and experience in a regulated environment

Strong problem-solving skills, sound judgment, and attention to detail

Excellent written, verbal, and technical communication skills

Demonstrated ability to proactively communicate progress, risks, decisions, and resource needs

Proven ability to prioritize competing work, maintain focus, own deliverables, and provide clear, timely progress updates

Ability to balance hands-on engineering with project execution, stakeholder alignment, and business priorities

Preferred Qualifications

Knowledge of cell therapy development and manufacturing processes

Familiarity with QbD principles

Experience applying DoE approaches to method development

Experience with data analysis and visualization tools such as Prism, JMP, or FlowJo

Experience with computer-aided design tools such as AutoCAD or Fusion 360

Experience using 3D printing for laboratory automation applications

Experience with LIMS such as Benchling or Labguru, and their integration with laboratory automation schedulers

The annual base pay (or hourly rate of compensation) for this position ranges from $103,286.40 to $154,929.60. Our positions offer eligibility for various incentives—an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans.

Date Posted 16-Oct-2026

Closing Date 29-Oct-2026 Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.