Senior Clinical Research Associate

BACK TO JOBS Senior Clinical Research Associate APPLY NOW Senior Clinical Research Associate Company: Clinical-Stage Oncology Biotechnology Company Location: Remote, United States Work Arrangement: Home-Based with Regional Travel Engagement: Contract Consulting Role The Opportunity Brio has partnered with a clinical-stage biotechnology company developing next-generation targeted radiotherapies for cancer to recruit a Senior Clinical Research Associate . This consultant will independently monitor assigned clinical sites and build productive relationships with investigators and research teams. The position requires experienced judgment in identifying operational and quality risks, reviewing clinical documentation, and ensuring timely resolution of issues affecting participant safety, regulatory compliance, and study execution. Key Responsibilities Conduct site qualification, initiation, interim monitoring, and closeout visits. Evaluate site readiness, including staffing, facilities, equipment, pharmacy, laboratory, imaging, and investigational product capabilities. Review informed consent documentation, source records, case report forms, regulatory files, and protocol compliance. Perform source data review and verification in accordance with the monitoring plan. Monitor participant eligibility, safety reporting, investigational product accountability, protocol deviations, and data quality. Build effective working relationships with investigators, coordinators, pharmacy teams, and other site personnel. Track monitoring findings, follow-up actions, and site performance through timely resolution. Escalate safety, enrollment, quality, compliance, and operational concerns appropriately. Prepare accurate, clear, and timely monitoring reports and follow-up communications. Support site enrollment, inspection readiness, corrective-action planning, and study closeout. Collaborate with Clinical Operations, Medical, Safety, Data Management, Quality, and external partners. Qualifications Bachelor’s degree in life sciences, nursing, pharmacy, or a related discipline, or equivalent clinical research experience. Significant CRA experience with recent independent onsite monitoring responsibility. Demonstrated experience managing an assigned portfolio of clinical sites. Comprehensive knowledge of ICH-GCP, FDA requirements, source documentation, and clinical monitoring practices. Strong site-management, documentation, communication, and problem-solving capabilities. Ability to identify risks early, exercise independent judgment, and drive site actions to completion. Oncology monitoring experience is strongly preferred. Experience with radiopharmaceuticals, nuclear medicine, prostate cancer, or complex oncology studies is highly desirable. Familiarity with radiation-safety procedures, radioactive material handling, nuclear-medicine facilities, or imaging requirements is beneficial. Ability to meet regional and national travel expectations. Why Consider This Opportunity? Innovative oncology platform: Support clinical development of next-generation targeted radiotherapies designed to deliver radioactive payloads directly to cancer cells. Site partnership: Help investigators and research teams execute complex oncology studies consistently and effectively. Quality ownership: Identify emerging risks and lead practical follow-through that protects participants and study integrity. Field responsibility: Independently manage an assigned clinical-site portfolio with remote flexibility and regional travel. Cross-functional exposure: Collaborate with clinical, medical, safety, quality, data, imaging, and nuclear-medicine stakeholders. Travel This is a home-based position requiring regional and occasional national travel based on site assignments and study needs. Specific territory, allocation, and anticipated travel frequency will be discussed during the interview process. Interested? Submit your resume to Brio to learn more about the organization, its oncology pipeline, and the consulting engagement. Additional details on contract duration, allocation, compensation, travel expectations, and the full job description will be provided after an initial resume review. Brio Resource Group partners with emerging and high-growth life sciences companies to recruit executives, functional leaders, and specialized professionals.