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South San Francisco, CA jobs, layoffs and employers

72 open professional jobs in South San Francisco. South San Francisco is in San Mateo County.

Jobs in South San Francisco

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Employers hiring most in South San Francisco

  1. Newlimit14 open roles
  2. Gritt Robotics9 open roles
  3. Marea Therapeutics7 open roles
  4. Westmag6 open roles
  5. Natera5 open roles
  6. Axiom Bio4 open roles
  7. Blue Matter Consulting4 open roles
  8. IDEAYA Biosciences4 open roles
  9. Alumis3 open roles
  10. Denali Therapeutics3 open roles

South San Francisco layoffs

No WARN layoff notices naming South San Francisco in the last 12 months are on file. WARN covers employers with 100 or more workers, so smaller layoffs are not in it.

All layoff notices in the state

Workforce development and job centers

The public workforce board and American Job Centers serving South San Francisco. They offer free help with job search, training and filing for benefits.

San Mateo County economy

  • 4.0%

    unemployment, Aug 2026

    4.3% the month before

  • 408,396

    in the labor force

    Source: BLS Local Area Unemployment Statistics

  • 745,100

    people in San Mateo County

    Source: U.S. Census Bureau

  • $156,000

    median household income

    Source: Census ACS

  • 55%

    of workers in white-collar occupations

    Management, business, financial and professional; Census ACS

More cities in San Mateo County

All of California

Laid off or looking for work in South San Francisco?

See what to do first and the jobs open near you.

See your options after a layoff

Sources: WARN notices from California’s published record; job counts from our live job board, taken from employers’ own career sites; IPEDS for colleges; CareerOneStop for workforce boards and job centers; Census Bureau and BLS for county figures.