South Carolina nonprofits: chambers, economic development and workforce organizations

32 South Carolina nonprofits with $1 million or more in annual revenue, from IRS records, and what is happening in the South Carolina job market around them. Staff can claim an organization’s page and set up a free workspace.

What matters to South Carolina nonprofits right now

4.3%
unemployment, Aug 2026
BLS, counties summed
2
open grants for nonprofits
Grants.gov and SAM.gov
12
local workforce boards

South Carolina workforce boards · South Carolina economic development organizations · White Collar Employment Report

Grants open to South Carolina nonprofits

CHIPS Incentives Program - Facilities for Semiconductor Materials and Manufacturing Equipment
National Institute of Standards and Technology · closes Nov 1, 2026
NLM Institutional Grants for Research Training in Biomedical Informatics, Data Science, and AI (T15 Independent Clinical Trial Not Allowed)
National Institutes of Health · closes Feb 11, 2027 · up to $775k

Chambers of commerce and business associations

Chambers of commerce and business associations in South Carolina, largest first
Organization	City	Annual revenue
Myrtle Beach Area Chamber of Commerce	Myrtle Beach	$83.6M
Hilton Head Island Bluffton Chamber of Commerce	Hilton Head	$12.4M
Greater Greenville Chamber of Commerce	Greenville	$3.9M
North Myrtle Beach Chamber of Commerce inc	N Myrtle Bch	$3.7M
Charleston Metro Chamber of Commerce	N Charleston	$3.6M
Georgetown County Chamber of	Georgetown	$2.5M
Greater Columbia Chamber of Commerce	Columbia	$1.7M
Greater Aiken Chamber of Commerce	Aiken	$1.2M
Greater Summerville-dorchester County Chamber of Commerce	Summerville	$1.1M
Greater Lexington Chamber of Commerce	Lexington	$1.0M

Economic development organizations

Economic development organizations in South Carolina, largest first
Organization	City	Annual revenue
Southern Carolina Regional Development Alliance	Barnwell	$10.6M
Palmetto Economic Development Corp	Columbia	$4.6M
Charleston Regional Development Alliance	Charleston	$4.3M
Lee and Sumter County Alliance	Sumter	$4.1M
Upstate South Carolina Alliance inc	Greenville	$3.2M
Business Development Corporation of Clarendon County	Manning	$3.1M
Charleston Redevelopment Corporation	Charleston	$3.0M
North Eastern Stragetic Alliance inc	Florence	$3.0M
Economic Development Partnership	Aiken	$3.0M
Northside Development Corporation	Spartanburg	$3.0M
Greenville Area Development Corporation	Greenville	$2.5M
Central Carolina Economic Development Alliance	Columbia	$2.4M
South Carolina Association for Community Economic Development	Charleston	$2.1M
South Carolina I-77 Alliance	Richburg	$1.9M
Myrtle Beach Regional Economic Development Corp	Conway	$1.8M
Institute for Strategic and Equitable Development	Charleston	$1.6M
Beaufort County Economic Development Corporation	Beaufort	$1.1M

Workforce development organizations

Workforce development organizations in South Carolina, largest first
Organization	City	Annual revenue
Chesterfield-marlboro Counties Economic Opportunity Council inc	Cheraw	$7.7M
Brighter Future Employment Services	Columbia	$6.3M
Great Plains Enterprises inc	Walhalla	$4.2M
Talent Market inc	Mt Pleasant	$3.6M
Sc Vocations & Individual Advancement	Greenville	$2.4M

Run a South Carolina nonprofit?

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Sources: organization names, cities, revenue and filing years from IRS tax-exempt organization records; unemployment from the Bureau of Labor Statistics; grants from Grants.gov and SAM.gov.