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Middlesex County, MA jobs, unemployment and layoffs

Middlesex County’s unemployment rate is 4.0%. Employers filed 4 layoff notices here in the last 12 months. 4,479 open professional jobs are in its cities.

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Middlesex County economy

  • 4.0%

    unemployment, Aug 2026

    4.3% the month before

  • 937,295

    in the labor force

    Source: BLS Local Area Unemployment Statistics

  • 1,622,896

    people in Middlesex County

    Source: U.S. Census Bureau

  • $126,779

    median household income

    Source: Census ACS

  • 61%

    of workers in white-collar occupations

    Management, business, financial and professional; Census ACS

Middlesex County layoffs

  • 4

    WARN layoff notices, last 12 months

  • 422

    workers named

    A floor: states may leave out counts

  • 4

    employers

WARN notices filed in Middlesex County, newest first
Notice dateEmployerCity or countyWorkersTypeSource
TScan Therapeutics Inc.Takes effect Nov 2, 2026Waltham96—State record
P1 Logistics LLCLittleton77—State record
*Updated* EMD Serono Research Development Institute, Inc.Billerica20—State record
Blueprint Medicines CorporationCambridge229—State record

All layoff notices in the state

Employers hiring most in Middlesex County

Employers with the most open professional roles in this county’s cities. The county is taken from each job’s city, so roles with no city are not counted.

  1. RTX211 open roles
  2. Harvard University117 open roles
  3. Formlabs86 open roles
  4. Alnylam Pharmaceuticals83 open roles
  5. Biogen78 open roles
  6. Takeda Development Center Americas72 open roles
  7. Moderna64 open roles
  8. Staples61 open roles
  9. Anduril Industries60 open roles
  10. Macom56 open roles

Largest employers headquartered in Middlesex County

Employee counts with a year are published figures (Wikidata). Other sizes are estimates from our company directory, not payroll counts.

Colleges in Middlesex County

Colleges in Middlesex County
CollegeCityTypeStudents
Harvard UniversityCambridgePrivate nonprofit 4-year20,000+
Boston CollegeChestnut HillPrivate nonprofit 4-year10,000–19,999
Massachusetts Institute of TechnologyCambridgePrivate nonprofit 4-year10,000–19,999
Tufts UniversityMedfordPrivate nonprofit 4-year10,000–19,999
University of Massachusetts-LowellLowellPublic 4-year10,000–19,999
Bentley UniversityWalthamPrivate nonprofit 4-year5,000–9,999
Brandeis UniversityWalthamPrivate nonprofit 4-year5,000–9,999
Framingham State UniversityFraminghamPublic 4-year1,000–4,999
Hult International Business SchoolCambridgePrivate nonprofit 4-year1,000–4,999
Lasell UniversityNewtonPrivate nonprofit 4-year1,000–4,999
Lesley UniversityCambridgePrivate nonprofit 4-year1,000–4,999
Regis CollegeWestonPrivate nonprofit 4-year1,000–4,999
Hebrew CollegeNewtonPrivate nonprofit 4-yearUnder 1,000
Longy School of Music of Bard CollegeCambridgePrivate nonprofit 4-yearUnder 1,000
Pope St John XXIII National SeminaryWestonPrivate nonprofit 4-yearUnder 1,000
William James CollegeNewtonPrivate nonprofit 4-yearUnder 1,000

Conferences in Middlesex County

Industry conferences and trade shows held in Middlesex County. 1 with dates announced.

  • MIT Sloan CIO Symposium

    May 18, 2027 · Cambridge, MA

    Paid ticket. Price not seen.

  • dmi:Design Leadership Conference

    Usually September (next dates not announced) · Cambridge, MA

    Ticket $1,100 to $1,300. 2026 fees per dmi.org: members $1,100, non-members $1,300; 2027 not announced.

  • MIT CDOIQ Symposium

    Usually July (next dates not announced) · Cambridge, MA

    Ticket $950 to $1,950. 2027 pricing not published; prior editions listed roughly $950 to $1,950.

  • MIT ETA Summit

    Usually February (next dates not announced) · Cambridge, MA

    Paid ticket. 2026 edition (Feb 27-28) sold out/closed; 2027 not announced.

All conferences

Workforce development and job centers

The public workforce board and American Job Centers serving Middlesex County. They offer free help with job search, training and filing for benefits.

  • MassHire Greater Lowell Workforce Board

    Towns: Billerica, Chelmsford, Dracut, Dunstable, Lowell, Tewksbury, Tyngsborough, Westford

  • MassHire North Central Workforce Board

    Towns: Ashburnham, Ashby, Ayer, Barre, Berlin, Bolton, Clinton, Fitchburg, Gardner, Groton, Harvard, Hubbardston, Lancaster, Leominster, Lunenburg, Pepperell, Princeton, Shirley, Sterling, Templeton, Townsend, Westminster, Winchendon

  • Metro North Regional Employment Board

    Towns: Arlington, Belmont, Burlington, Cambridge, Chelsea, Everett, Malden, Medford, Melrose, North Reading, Reading, Revere, Somerville, Stoneham, Wakefield, Watertown, Wilmington, Winchester, Winthrop, Woburn

  • Metro South/West Workforce Board, Inc.

    Towns: Acton, Ashland, Bedford, Bellingham, Boxborough, Brookline, Canton, Carlisle, Concord, Dedham, Dover, Foxborough, Framingham, Franklin, Holliston, Hopkinton, Hudson, Lexington, Lincoln, Littleton, Marlborough, Maynard, Medfield, Medway, Millis, Natick, Needham, Newton, Norfolk, Norwood, Plainville, Sharon, Sherborn, Southborough, Stow, Sudbury, Walpole, Waltham, Wayland, Wellesley, Weston, Westwood, Wrentham

  • MassHire Metro North Career Center in Cambridge

    Cambridge · Comprehensive · 617-661-7867

    Mon - Fri 8:30am-4:30pm

  • MassHire Framingham Career Center

    Framingham · Comprehensive · 508-861-7993

    Mon - Thurs 8:45am - 4:30pm; Fri 9:45am - 4:30pm- Virtual Only

  • MassHire Lowell Career Center

    Lowell · Comprehensive · 978-458-2503

    Mon, Wed, Thur 8:00am - 5:00pm, Tues 8:00am-8pm; Friday 8:00am-12:00pm

  • MassHire Metro North Career Center

    Woburn · Comprehensive · 781-932-5500

    Monday - Friday 8:30am - 4:30pm

Cities in Middlesex County

Other Massachusetts counties

All of Massachusetts

Laid off or looking for work in Middlesex County?

See what to do first and the jobs open near you.

See your options after a layoff

Sources: Census Bureau and BLS (county unemployment is not seasonally adjusted); WARN notices from Massachusetts’s published record; job counts from our live job board; IPEDS for colleges; CareerOneStop for workforce boards and job centers.