Senior Systems Engineer
Mayo Clinic
Rochester, MN · Posted October 13, 2026
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Where Rochester, MN ranks
Where Rochester, MN placed in our monthly rankings, month by month. Each month stays online at its own address.
November 2026
- #5Cities with the most hybrid jobs in the Great Lakes19% · of 50
- #7Cities with the most hybrid jobs in the Midwest19% · of 67
- #8Best cities for AI-skill jobs in the Midwest10% · of 69
- #8Best cities for AI-skill jobs in the Great Lakes10% · of 53
- #10Best cities for entry-level jobs that want AI skills in the Great Lakes4% · of 38
- #12Best cities for entry-level jobs that want AI skills in the Midwest4% · of 52
Rankings about engineering jobs
- Best cities for software and engineering jobs #1 San Francisco (3,412 openings)
- Best cities for engineering pay after cost of living #1 San Mateo ($216k)
- Most requested AI skills in engineering jobs #1 AI tools in daily work (6.1%)
- AI tools named most often in engineering jobs #1 Claude (1.7%)
- Employers with the most engineering jobs #1 Amazon (2,992 roles)
Pay compared with the market
This listing does not state pay. Across 43 open senior systems engineer listings that state pay, the middle half runs $149,500 to $193,000 and the median is $174,000.
Listed pay is what employers advertise, not what people are paid.
Senior Systems Engineer salaries by state · Check your own pay
How AI is used in this kind of work
Among computer occupations, all other, AI is already used for a large share of the tasks. Measured exposure for computer occupations, all other: 31% (high).
Share of this job’s tasks that AI is already used for at work, from real usage. It is not a forecast of job loss, and a low number means no use seen yet. Source: Anthropic Economic Index.
Skills this job asks for
Say which you have and which you want to build. We use it to match you to jobs like this one.
About the job
The Department of Laboratory Medicine and Pathology (DLMP) has openings for Senior Systems Engineer. In this role you will provide support to DLMP leadership with business strategy and planning, business process engineering, or business transformation. Additional responsibilities include:
Providing assistance in continuous improvement methods, which includes Lean, Six Sigma, and system/industrial engineering disciplines
Identifying opportunities and helping design, develop and implement expanded or redesigned services/strategies
Facilitating the introduction of new tools and/or methods to improve existing operations
Leading and managing basic to moderate projects at the work unit or division level independently
Training and mentoring teams on improvement tools
Devising and reviewing content and methods to teach continuous improvement concepts, and provide on-demand workshops, e-learning, webinars, and presentations
Transferring knowledge and facilitating staff development in proficient application of process improvement techniques
Providing mentorship to DLMP staff
Publishing posters, white papers, articles in business journals and/or presenting at conferences
*Individuals hired to this position are required to complete 2 years in this position before becoming eligible to apply to other positions within Mayo Clinic.
**This position is not eligible for visa sponsorship; Also, Mayo Clinic DOES NOT participate in the F-1 STEM OPT extension program.
To be considered for the Senior Systems Engineer position, you must meet the following requirements:
Master's degree in engineering, management, business administration, healthcare, computer science, or a similar field and 4 years of experience that includes several of the following areas of expertise: consulting/advising, continuous improvement, operations analysis, workflow analysis, staffing analysis, process engineering, systems analysis, leadership & facilitation, team building, and project management.
In lieu of a master's degree, you may be considered if you have a bachelor's degree in the same fields listed above with at least 6 years of experience in the above areas of expertise.
Additional Qualifications
A master's degree in industrial engineering is preferred.
This position requires you to live within a reasonable driving distance to Mayo Clinic in Rochester, Minnesota.
You will be required to obtain Mayo Quality Silver Fellow certification within 1 year of your start date.
Excellent interpersonal skills; effectively communicate as a liaison among DLMP operations.
Expertise, knowledge, and experience applying Lean, Six Sigma, other continuous improvement tools, and change management in a dynamic environment
Ability to lead projects independently
Successful collaboration with physicians, consultants, administrators, and/or allied health staff
Excellent time management, and facilitation skills
Working knowledge of Outlook, Excel, PowerPoint, and Visio are required
Application Requirements
*All must be included for your application to be considered :
CV/Resume
Cover letter
NACES detailed international equivalency for foreign degrees.
Internal candidates must provide their past three performance appraisals.
**DLMP employees that have been in current lab/position for less than 2 years must attach early release approval from supervisor.
***Non-DLMP internal applicants that have been in their current department/position for less than 1 year must attach early release approval from supervisor.
*International transcript :
MUST have a DETAILED equivalency evaluation.
MUST show US equivalent degree.
Evaluation MUST be completed from an organization listed as a member of the National Association of Credential Evaluation Services (NACES) www.naces.org OR the Association of International Credential Evaluators, Inc. (AICE) www.aice-eval.org .
Why Mayo Clinic
Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans – to take care of you and your family, now and in the future. And with continuing education and advancement opportunities at every turn, you can build a long, successful career with Mayo Clinic.
Benefits Highlights
Medical: Multiple plan options.
Dental: Delta Dental or reimbursement account for flexible coverage.
Vision: Affordable plan with national network.
Pre-Tax Savings: HSA and FSAs for eligible expenses.
Retirement: Competitive retirement package to secure your future.