Senior Project Manager - Pharmacy
Mayo Clinic
Rochester, MN · Posted November 10, 2026
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Where Rochester, MN ranks
Where Rochester, MN placed in our monthly rankings, month by month. Each month stays online at its own address.
November 2026
- #5Cities with the most hybrid jobs in the Great Lakes19% · of 50
- #7Cities with the most hybrid jobs in the Midwest19% · of 67
- #8Best cities for AI-skill jobs in the Midwest10% · of 69
- #8Best cities for AI-skill jobs in the Great Lakes10% · of 53
- #10Best cities for entry-level jobs that want AI skills in the Great Lakes4% · of 38
- #12Best cities for entry-level jobs that want AI skills in the Midwest4% · of 52
Rankings about clinical jobs
- Best cities for clinical jobs #1 New York (202 openings)
- Employers with the most clinical jobs #1 Veterans Health Administration (215 roles)
Pay compared with the market
This listing does not state pay. Across 169 open senior project manager listings that state pay, the middle half runs $115,500 to $167,500 and the median is $140,000.
Listed pay is what employers advertise, not what people are paid.
Senior Project Manager salaries by state · Check your own pay
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About the job
The Senior Project Manager (PM) works independently, assuming primary responsibility for planning, directing, coordinating, and delivering project activities through the entire project life cycle (from initiation through handoff to customer) that are major, complex, and business critical. The Senior PM is responsible for leading project objectives and completion on time, on budget, and in conformance with Mayo Clinic project management methodologies and standards.
The Senior Project Manager serves as the portfolio execution leader for Pharmacy Intelligence & Automation. This role is responsible for coordinating and driving strategic initiatives involving pharmacy analytics, automation, artificial intelligence (AI), reporting, operational transformation, and technology optimization across Mayo Clinic pharmacy practice.
The position provides program leadership for a growing portfolio of initiatives and supports enterprise-wide deployment of innovative solutions that improve medication safety, operational efficiency, workforce productivity, regulatory compliance, and financial stewardship. The successful candidate will demonstrate the ability to manage a complex portfolio of strategic initiatives, work effectively with executive leaders and frontline staff, establish governance processes, translate strategy into execution, develop roadmaps and executive-level communications, track value realization and return on investment, lead organizational change efforts, and coordinate analytics, automation, AI, and innovation initiatives across pharmacy.
In addition to managing complex individual projects, this role provides oversight and coordination for an enterprise portfolio of strategic initiatives, ensuring work is appropriately prioritized, governed, resourced, measured, and successfully adopted.
The Senior PM will lead large projects that have site- or enterprise-level strategic importance. Project work has high to very high risk and risk interdependencies, multiple interrelationships, and may have major costs associated. Responsible for managing established budgets, the Senior PM leads and provides direction in the development and tracking of project budgets. The position requires strict adherence to budget management practices and guidelines of both the assigned department and the institution.
The Senior PM independently leads problem-solving and decision-making activities within the scope of the project and change management process, taking reasonable and prudent actions to accomplish agreed-upon project objectives. This individual leverages extensive experience to manage large-scale initiatives and is highly competent in the implementation and sustainment of project outcomes. Advanced negotiation skills, strategic thinking, and innovative problem-solving are essential to this role.
In addition to traditional project management responsibilities, this role is expected to support portfolio governance, strategic planning, executive reporting, stakeholder engagement, organizational change management, resource coordination, and benefits realization activities for enterprise pharmacy initiatives.
The use and application of Agile, Lean, and continuous improvement methodologies is important to this role. The successful candidate must be comfortable leading both technology-focused and operational transformation initiatives while adapting project approaches to meet organizational needs.
Many of the items important to an Agile process are not unique to Agile. This individual may be responsible for monitoring scrum processes and scrum meetings. They may work to increase efficiency, motivate teams, and advocate for changes that ensure quality and timeliness. Responsibilities may include:
Guiding teams on Agile practices and values to implement critical projects.
Assessing team and organizational maturity and coaching teams to higher levels of performance and effectiveness.
Removing impediments and blockers or guiding teams to do so; escalating appropriately when necessary.
Building a trusting and collaborative environment where issues can be openly raised and resolved.
Facilitating completion of work without coercion, assignment, or directive management approaches.
Facilitating discussion, decision making, and conflict resolution.
Supporting and educating Product Owners, particularly regarding backlog development and backlog refinement.
May have direct and indirect reports and may be responsible for leading and developing project staff in a goal-oriented manner. The Senior Project Manager leads and demonstrates a project-focused culture at Mayo Clinic and serves as a mentor and advisor to others regarding project management practices, methods, and standards.
This role will frequently interact with executive leaders, pharmacy operational leaders, informatics professionals, analysts, technology teams, and clinical stakeholders. Success requires strong executive communication skills, strategic thinking, influence without authority, and the ability to translate organizational priorities into executable plans while managing multiple concurrent initiatives.
Examples of work may include:
Medication management reporting and business intelligence.
Pharmacy analytics and dashboard modernization.
Automation and workflow optimization initiatives.
AI and advanced analytics programs.
Epic-related pharmacy transformation efforts.
Drug shortage and inventory analytics.
Medication safety and diversion surveillance initiatives.
Operational excellence and continuous improvement programs.
Pharmacy technology and digital transformation initiatives.
Performs additional job-related functions as detailed by immediate supervisor.
Preferred Experience
Healthcare PMO leadership.
Enterprise digital transformation programs.
Clinical or pharmacy informatics.
Healthcare analytics, business intelligence, or data governance programs.
Operational excellence and continuous improvement initiatives.
AI, automation, or emerging technology implementations.
Experience working with executive governance structures, steering committees, and enterprise portfolios.
This position is a hybrid role, and the candidate must live within 100 miles of Rochester, Minnesota. On-site days will be purpose-driven and may include activities such as collaboration with colleagues, practice shadowing, and workflow observation. On-site requirements are estimated to be approximately two days per quarter.
This vacancy is not eligible for sponsorship/ we will not sponsor or transfer visas for this position. Also, Mayo Clinic DOES NOT participate in the F-1 STEM OPT extension program.
Bachelor's degree with 10 years’ experience in Project Management and business related activities or Master's degree with 7 years’ experience in Project Management. Education preference: project management, business administration, agile/scrum, management. Active (unexpired) Project Management Professional (PMP) certification is required.
Candidates should also include any certifications they have, which do not supersede the PMP certification, which may include but are not necessarily limited to Certified Product Management, Certified Scrum Master (CSM), Advanced Certified Scrum Master (A-CSM), PMI Agile Certified Practitioner, Risk Management Professional (RMP) and/or Certified Scrum Professional (CSP).
Why Mayo Clinic
Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans – to take care of you and your family, now and in the future. And with continuing education and advancement opportunities at every turn, you can build a long, successful career with Mayo Clinic.
Benefits Highlights
Medical: Multiple plan options.
Dental: Delta Dental or reimbursement account for flexible coverage.
Vision: Affordable plan with national network.
Pre-Tax Savings: HSA and FSAs for eligible expenses.
Retirement: Competitive retirement package to secure your future.