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Senior / Principal EHS Specialist

Calico

South San Francisco, CA · Posted October 6, 2026

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About the job

Who We Are:

Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.

Position Description:

Calico is seeking a Senior/Principal Environmental Health & Safety Specialist to join the EHS team. Calico EHS works directly with researchers, facilities and operations staff, to prevent accidents, resolve unsafe conditions, protect the environment, and provide consultation on environmental, health and safety practices and regulatory information. The role will be the primary owner for Environmental Programs, as well as own or assist with the implementation of several other EHS programs, promote safety practices and look for ways to offer continuous improvement in a fast paced, always changing start up environment. In this role, you will exercise a high degree of independent judgment to conduct comprehensive risk assessments, ensure regulatory compliance, and oversee government reporting. You will proactively analyze systemic risks, lead significant incident investigations, and implement effective CAPAs to mitigate organizational liability. An exceptional collaborator and communicator, you will interface seamlessly with lab, office, and operations staff, manage vendor performance, and design and deliver complex technical training. Additionally, you will lead small-to-medium or safety initiatives and facility modification reviews to champion a proactive culture of compliance or lead cross-functional teams for significant safety culture initiatives and strategic facility planning.

Position Responsibilities:

Environmental Programs owner:

Air, Water, Waste programsHazardous Waste (chemical and bio- hazardous waste) program

Work with vendors and lab members to manage waste appropriately

Permits and reporting for the above programs

Regulatory Environmental reporting requirements (CERS, biennial report, etc.)

Controlled Substances Program owner

Personal Protective Equipment (PPE) Program owner

Pandemic (e.g., COVID) Response (day-to-day activities/communications)

Life Safety Programs and Emergency Response

Building Evacuation Team Lead

First Aid / AED / Fire Boxes maintenance

Fire/Earthquake Drills Lead

Emergency action plan Lead

Worker’s Compensation liaison (HR Program Owner) and OSHA Log maintenance

Supervisor of on-site Hazardous Waste vendor staff

Assist with implementation and record keeping for Environmental Health and Safety programs such as: Radiation Safety, Biosafety, Chemical Safety, Physical Safety Programs, Ergonomics, Overall Training Programs/LMS, Occupational Health, Industrial Hygiene, and Contractor/Construction Safety

Serve as backup Chemical Hygiene, Biological Safety Officer, and as an alternate Radiation Safety Officer

Conduct IH surveys to identify processes that pose a risk to the health and safety of employees and make recommendations for improvement

Perform risk/exposure assessments pertaining to laboratory/chemical/biological safety, conduct lab audits, recommend and follow up on corrective actions

Respond to emergencies and spills

Conduct safety training and incident investigations

Help implement and maintain chemical inventory, SDS library, Learning Management System, regulatory reporting requirements (CERS, biennial report, etc.) and ensuring chemical and biohazard materials are properly stored

Work as a team member in implementing other environmental health and safety programs as needed

Assist with the Calico Safety Committee and follow up with action items

Assist with IACUC protocols and tasks associated with Vivarium

Help manage Learning Management System to maintain overall compliance

Position Requirements:

Bachelor's degree in scientific or safety related field with 5-8+ years’ experience working in an EH&S department, preferably in the life science industry; 2-5+ years’ experience with a Masters/PhD

Certification (ASP/CSP/CIH) preferred

Ability to keep accurate records, be highly organized, prioritize time and adjust goals quickly in a fast-paced environment

Ability to solve problems, find novel solutions and build programs from the ground up in a startup environment

Experience with Hazardous Waste Program Management and other Environmental Programs

Knowledge and experience with EHS Systems and programs (e.g., Biosafety, Respiratory Protection, Chemical Hygiene Plan, Injury and Illness Prevention Plan, LOTO, etc.)

Ability to communicate effectively with stakeholders and interact with a large group of people with diverse needs and goals while also meeting the overall goals and objectives of the company

Ability to adapt style and use persuasion in delivering messages that relate to the wider firm business

Must be willing to work onsite 5 days a week

The estimated base salary range for this role is $145,000 - $180,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.