Principal Machine Learning Engineer
Genentech
New York, NY · $193k–$358k a year · Posted November 6, 2026
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Where New York, NY ranks
Where New York, NY placed in our monthly rankings, month by month. Each month stays online at its own address.
November 2026
- #1Best cities for operations jobs1,429 openings · of 100
- #1Best cities for sales jobs2,774 openings · of 78
- #1Best cities for finance jobs1,932 openings · of 78
- #1Best cities for data and analytics jobs1,713 openings · of 58
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Rankings about data & analytics jobs
- Best cities for data and analytics jobs #1 New York (1,713 openings)
- Best cities for data and analytics pay after cost of living #1 Foster ($232k)
- Most requested AI skills in data and analytics jobs #1 Machine learning engineering (17.1%)
- AI tools named most often in data and analytics jobs #1 Databricks (7.6%)
- Employers with the most data and analytics jobs #1 Amazon (711 roles)
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Pay compared with the market
This listing pays about $275,000 a year. Across 28 open principal machine learning engineer listings that state pay, the middle half runs $246,000 to $315,000 and the median is $272,500. That is inside the middle half of those listings, 1% above the median.
Listed pay is what employers advertise, not what people are paid.
Principal Machine Learning Engineer salaries by state · Check your own pay
How AI is used in this kind of work
Among computer occupations, all other, AI is already used for a large share of the tasks. Measured exposure for computer occupations, all other: 31% (high).
Share of this job’s tasks that AI is already used for at work, from real usage. It is not a forecast of job loss, and a low number means no use seen yet. Source: Anthropic Economic Index.
Genentech has filed one layoff notice in the last twelve months, covering 103 workers, most recently June 2026. These are public filings with state labor departments, and an open role can sit alongside them. See the filings
Skills this job asks for
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About the job
...Discovery (AIDD) group (Prescient Design), we are revolutionizing drug discovery with cutting-edge machine learning. We are seeking a Principal Machine Learning Engineer to join our Foundation Models team. In this role, you will drive the engineering, scaling, and operationalization...