Global Accounts Payable Manager

Company Overview Rhythm is a global, commercial-stage biopharmaceutical company committed to transforming the lives of patients living with rare neuroendocrine diseases. We develop medicines for previously untreatable or undertreated diseases. We recognize the courage it takes for patients and their caregivers to begin their journey of advocacy to find the answers they need. Their courage inspires us to challenge convention, ask bold questions and seek answers for them. Every day, we strive for excellence through our willingness to adapt, learn, and our tenacity to overcome barriers, together.

Opportunity Overview Rhythm Pharmaceuticals is seeking a Global Accounts Payable Manager to join our Finance and Accounting team. The Global Accounts Payable Manager is responsible for leading and optimizing the end‑to‑end accounts payable function across multiple regions and legal entities. This role ensures timely, accurate, and compliant processing of vendor payments for both the US and international entities, while driving standardization, automation, and continuous improvement across global AP operations.

Reporting to the Senior Director, Accounting & Financial Reporting, this role is a critical member of the accounting operations team, with interaction with the Corporate Controller, International Controller, Chief Financial Officer, and many other operational stakeholders.

Responsibilities and Duties Lead and manage global accounts payable operations across multiple countries, currencies, and entities

Oversee vendor management, invoice processing and employee reimbursements

Ownership of global payment runs and AP mailbox

Lead the travel and expense reimbursement function, including policy oversight, system administration and optimization of Concur functionality.

Ensure compliance with internal controls, SOX requirements, local statutory regulations, and company policies

Drive standardization of AP processes and controls across regions while balancing local regulatory needs

Manage and develop regional AP teams, including performance management, training, and career development

Serve as the primary escalation point for complex vendor issues, payment discrepancies, and audit inquiries

Partner with Procurement and business stakeholders to improve purchase‑to‑pay (P2P) efficiency and vendor experience, in newly implemented Coupa system

Own AP‑related month‑end and year‑end close activities, including accruals, reconciliations, and reporting

Lead AP participation in internal and external audits; ensure timely remediation of findings

Drive automation and process improvement initiatives (e.g., invoice capture, workflow tools, ERP enhancements)

Work with our international team to monitor and report key performance indicators (KPIs) such as invoice cycle time, payment accuracy, invoices processed, and aging

Support global ERP implementations, system upgrades, and integrations related to AP processes

Perform other responsibilities across the accounting department as needed.

Qualifications and Skills Bachelor’s degree in accounting or finance preferred

5+ years of progressive experience in a public-company accounts payable group; Biotech/Pharmaceutical preferred

2+ years of people management experience, preferably managing geographically dispersed teams

Ability to drive continuous improvement to optimize processes and maintain a solution-oriented mindset

Ability to work both independently and deliver on responsibilities within a highly collaborative environment

Excellent attention to detail, project management and organizational skills

Strong knowledge of AP processes, internal controls, and SOX compliance

Demonstrated ability to lead process transformation and operational scalability

Strong analytical, problem‑solving, and organizational skills

Excellent and timely communication as well as stakeholder management skills

Ability to operate effectively in a fast‑paced, global environment across time zones

Proficiency in Excel

Experience working with ERP systems (Microsoft D365, Oracle Fusion, NetSuite, etc.) and AP/P2P automation tools is required Experience with Coupa is strongly preferred

This role is based out of our corporate office in Boston, Massachusetts. Rhythm operates in a hybrid-work model. Candidates applying must be willing and able to be in the Boston office in coordination with their department and business needs. This role may involve some travel.

The expected salary range for this position is $110,000 - $165,000. Actual pay will be determined based on experience, level, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and company performance. This role may be eligible for benefits and other compensation such as restricted stock units.

More about Rhythm We are a dynamic and growing global team spanning more than a dozen countries. At Rhythm we are dedicated to transforming the lives of patients living with rare neuroendocrine diseases by rapidly advancing care and precision medicines that address the root cause. Our team is passionate about expanding access to reach more patients and developing novel therapies for other rare neuroendocrine diseases, including congenital hyperinsulinism.

At Rhythm, our core values are: We are committed to advancing scientific understanding to improve patients’ lives.

We are inspired to tackle tough challenges and have the courage to ask bold questions.

We are eager to learn and adapt.

We believe collaboration and ownership are foundational for our success.

We value the unique contribution each individual brings to furthering our mission.

Inherent in our core values is the commitment to act ethically and with integrity in all we do.

Rhythm is an equal employment opportunity employer and does not discriminate against any applicant because of race, creed, color, age, national origin, ancestry, religion, gender, sexual orientation, disability, genetic information, veteran status, military status, application for military service, or any other class protected by state or federal law.

Headquartered in Boston, Rhythm is proud to have been named one of the Top Places to Work in Massachusetts.