Sr Scientist, Drug Metabolism

At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world’s biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference.

Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we’re looking for the next wave of passionate and ambitious people ready to make a direct impact.

We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together.

Job Description

This position is onsite at our global headquarters in Foster City, CA.

Essential Duties and Job Responsibilities:

P rovide advanced PK and PK/PD modeling expertise on project teams across discovery and development stages, guiding the design and interpretation of nonclinical PK, toxicology, and pharmacology studies.

Drive quantitative DMPK strategy for programs, collaborating with interdisciplinary teams to integrate modeling approaches into decision-making; communicate modeling insights and align strategies with scientists, collaborators, and management.

Design, implement, and validate complex PK/PD and mechanistic models to address translational questions, support dose selection, and predict first-in-human exposures.

Develop and refine modeling workflows for nonclinical study design, including simulation-based approaches to optimize study parameters and interpret outcomes, with application of AI-based enhancements where possible

Work closely with project teams, line management and CROs to assure high quality and timely delivery of documents for regulatory submissions.

Participate in business development and licensing evaluations.

Knowledge, Experience and Skills:

 Ph.D. with 5+ years of post-graduate industry experience in PK, drug metabolism, pharmaceutics, or a related life science field, with a primary focus on quantitative modeling of agents (small molecules, biologics, antibody-drug conjugates, targeted protein degraders etc.) for PK and PK/PD characterization across discovery and development.

 Strong foundation in PK and PD principles , with demonstrated ability to translate these concepts into mathematical models.

 Extensive experience in mechanistic PK/PD and multi-compartmental modeling , including proficiency with software platforms such as Phoenix/WinNonlin, MATLAB/SimBiology, GastroPlus, SimBiology, R , or equivalent modeling tools.

 Proven ability to design, implement, and interpret complex modeling workflows , determine next steps based on quantitative insights, and effectively communicate results to project teams and senior management.

 Hands-on experience in application of AI, in model-building and in streamlining and automation of workflows.

 Demonstrated intellectual curiosity and commitment to staying current with advances in biologics DMPK and modeling methodologies, supported by a track record of external visibility through publications, presentations, and/or professional organization involvement.

 Excellent communication skills, particularly the ability to explain complex topics to diverse audiences.

The salary range for this position is: $169,320.00 - $219,120.00. Gilead considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package. Benefits include company-sponsored medical, dental, vision, and life insurance plans*.

For additional benefits information, visit:

https://www.gilead.com/careers/compensation-benefits-and-wellbeing

* Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans.

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