Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types.

Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology & oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com .

Prime Medicine is a clinical-stage biotechnology company creating the next generation of gene editing therapies. Our Prime Editing platform is versatile, precise, and efficient, with the potential to address more than 90% of known disease-causing genetic mutations. We have three programs in the clinic: an ex vivo cell therapy for an ultra-rare disease advancing toward a Biologics License Application (BLA), and two in vivo liver-targeting LNP Prime Editor programs, with more in development. We are a mission-driven team working in a lean, fast-moving environment.

Position Overview

Reporting directly to the Chief Technology Officer, the Executive Director of Supply Chain and External Manufacturing is a member of the Technology, Development and Operations (TDO) leadership team. You will own Prime Medicine’s end-to-end supply chain, from raw materials through clinical supply and commercialization, with direct accountability for materials management and for supporting internal planning and manufacturing needs. You will manage our external manufacturing partners, lead a highly functional lean team, and serve as the primary partner to Finance for TDO external spend. We are looking for a leader who embraces AI as a core part of how supply chain and external manufacturing run at Prime Medicine, from forecasting and materials visibility to partner performance and cost modeling. This role is for someone who thrives in ambiguity, is energized by building, and pairs strategic thinking with hands-on execution.

Primary Responsibilities

Partner with the CTO and TDO leadership to define manufacturing and supply chain strategy, including network design, make-vs-buy decisions, and partner selection.

AI-enabled operations. Lead the use of AI and digital tools across supply chain and external manufacturing, including demand forecasting, materials and inventory visibility, partner performance monitoring, contract and cost modeling, and logistics tracking, as well as keeping the function ahead of new tools as they emerge.

Materials management. Own materials management across the portfolio, including forecasting, sourcing, purchasing, and inventory of raw materials, critical starting materials, and components, so materials are available on time for each program.

Planning and supply operations. Support internal planning and the manufacturing needs of each program; deliver labeling, packaging, shipping, and cell therapy logistics on time and in full; and resolve supply risks before they affect timelines.

External manufacturing and partners. Build and manage a network of CDMOs, CROs, and critical suppliers, including contracts, governance, performance, and qualification of new partners.

Clinical and commercial readiness. Ensure supply chain documentation and external site readiness support IND and BLA submissions, working with CMC, Regulatory, Quality, Non-clinical Development, Clinical, and program teams.

Own TDO budget development for external spend, cost projections, and financial reporting in close partnership with functional leaders and Finance.

Leadership . Lead, coach, and inspire your team of supply chain/external manufacturing professionals and indirect colleagues across TDO; foster a culture of accountability, continuous improvement, and collaborative problem-solving and goal attainment

Preferred Qualifications

Bachelor’s degree in a relevant technical discipline; advanced degree (MS, MBA, or PhD) preferred

15–20+ years of progressive experience in supply chain, technical operations, external manufacturing, process development, or MSAT within biotech or pharma

Direct ownership of materials management and clinical supply for clinical-stage programs

Experience managing CDMOs and CROs, including negotiating MSAs and SOWs

Experience with cell therapy and/or LNP or nucleic acid programs; experience supporting IND/CTA and BLA/MAA submissions

Financial acumen, including ownership of operating budgets and multi-year cost projections

Track record of implementing AI or digital tools that improved forecasting, visibility, or decision-making in supply chain or operations, and of changing how teams work as a result

Strong change management, project management, and communication skills, with the ability to build trust with partners, Finance, and senior leadership

Plus: lean, fast-moving biotech; ultra-rare disease or small patient population experience

Why Prime Medicine

Your work will matter: our programs have the potential to be curative therapies for patients with no other options, and this role directly enables that. You will be part of the TDO leadership team, with direct access to the CTO and interact with other Executive leaders, and you will shape how AI is applied to supply chain and manufacturing at a company where it is a growing priority. You will have ownership from day one in building how Prime Medicine delivers for patients.

Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Location: Cambridge, MA | Reports to: Chief Technology Officer | TDO Leadership Team Member

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity).

Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks.

Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.

U.S. Pay Range $295,000 — $312,000 USD