Senior Microsoft 365 Platform Engineer
Repligen
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Remote · Waltham, MA · Posted November 3, 2026
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Where Waltham, MA ranks
Where Waltham, MA placed in our monthly rankings, month by month. Each month stays online at its own address.
November 2026
- #1Best cities for life sciences and biotech pay after cost of living$221k · of 10
- #2Best cities for software and engineering jobs in New England184 openings · of 24
- #2Best all-round cities for new graduates in New England59 / 100 · of 11
- #2Best all-round cities for mid-career professionals in New England67 / 100 · of 11
- #2Best all-round cities for remote workers in New England80 / 100 · of 11
- #2Best all-round cities for AI careers in New England80 / 100 · of 11
Rankings about engineering jobs
- Best cities for software and engineering jobs #1 San Francisco (3,412 openings)
- Best cities for engineering pay after cost of living #1 San Mateo ($216k)
- Most requested AI skills in engineering jobs #1 AI tools in daily work (6.1%)
- AI tools named most often in engineering jobs #1 Claude (1.7%)
- Employers with the most engineering jobs #1 Amazon (2,992 roles)
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Among computer occupations, all other, AI is already used for a large share of the tasks. Measured exposure for computer occupations, all other: 31% (high).
Share of this job’s tasks that AI is already used for at work, from real usage. It is not a forecast of job loss, and a low number means no use seen yet. Source: Anthropic Economic Index.
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About the job
A a highly skilled Senior Microsoft 365 Platform Engineer to lead the engineering, administration, governance, security, and continuous improvement of our global Microsoft 365 platform. This role will serve as the technical lead for Microsoft 365 collaboration, SharePoint Online, Identity & Access Management (IAM), Entra ID, and endpoint management services, ensuring secure, scalable, and reliable digital workplace solutions across the enterprise. Key Responsibilities
Own the administration, support, governance, and continuous improvement of Microsoft 365 services, including SharePoint Online, Teams, Exchange Online, OneDrive, Entra ID, and Intune.
Serve as the Tier 3 escalation point and technical authority for Microsoft 365 platform issues and initiatives.
Design and implement secure, scalable M365 solutions aligned with enterprise architecture and security standards.
Lead SharePoint governance, permissions management, site lifecycle management, collaboration standards, and migration initiatives.
Administer and enhance Identity & Access Management (IAM) capabilities including Hybrid Identity, Single Sign-On (SSO), Multi-Factor Authentication (MFA), Conditional Access, Privileged Identity Management (PIM), and Identity Governance.
Support enterprise application integrations using SAML, OAuth, OpenID Connect, and SCIM.
Manage endpoint solutions through Microsoft Intune and Windows Autopilot, including device provisioning, compliance, application deployment, and endpoint security.
Develop automation and operational improvements using PowerShell and Microsoft Graph.
Monitor platform health, performance, security posture, adoption, and compliance metrics.
Partner with Cybersecurity teams to implement Microsoft 365 security, compliance, and governance controls.
Participate in incident response, root cause analysis, and continuous service improvement activities.
Create and maintain architecture documentation, standards, runbooks, and operational procedures.
Evaluate Microsoft roadmap enhancements and lead the adoption of new technologies and platform capabilities
Qualifications
Bachelor's degree in Information Technology, Computer Science, or related field, or equivalent experience.
7+ years of hands-on Microsoft 365 administration and engineering experience in a medium-to-large enterprise.
Deep expertise in: Microsoft 365 Administration
SharePoint Online Administration & Governance
Microsoft Teams
Exchange Online
OneDrive for Business
Microsoft Entra ID (Azure AD)
Identity & Access Management (IAM)
Microsoft Intune
Strong experience with Hybrid Active Directory and Entra ID environments.
Expertise implementing and managing SSO, MFA, Conditional Access, RBAC, PIM, and Identity Governance.
Strong PowerShell scripting and Microsoft Graph automation experience.
Experience supporting endpoint management, Windows Autopilot, and modern device management.
Strong understanding of Microsoft 365 security, compliance, governance, and collaboration technologies.
Experience with Microsoft Defender, Purview, ServiceNow, and ITIL processes preferred.
Experience supporting global organizations and geographically distributed teams.
Preferred Certifications
Microsoft 365 Certified: Enterprise Administrator Expert (MS-102)
Microsoft Certified: Identity and Access Administrator Associate (SC-300)
Microsoft Certified: Endpoint Administrator Associate (MD-102)
Microsoft Certified: Cybersecurity Architect Expert (SC-100)
Our mission is to inspire advances in bioprocessing as a trusted partner in the production of biologic drugs that improve human health worldwide. Focused on cost and process efficiencies, we deliver innovative technologies and solutions that help set new standards in bioprocessing. The estimated salary range for this role, based in the United States of America is $140,000-$180,000. Compensation decisions are dependent on several factors including, but not limited to an individual's qualifications, location, internal equity, and alignment with market data. Additionally, employees are eligible to participate in one of our variable cash programs (bonus or commission) and eligible roles may receive equity as part of the compensation package. We offer a wide range of benefits such as paid time off, health/dental/vision, retirement benefits and flexible spending accounts. All compensation and benefits information will be confirmed in writing at the time of offer.