Sr Manager, Enterprise Business Systems
Iambic Therapeutics
San Diego, CA · $144k–$180k a year · Posted November 6, 2026
Just laid off? Start here: a plan for the first weeks
See every open role at Iambic Therapeutics
More in California job market · All Sr Manager jobs (173) · Pharmaceuticals & Biotech · Engineering jobs
More roles at Iambic Therapeutics
- Research Scientist II/Senior Research Scientist, Medicinal Chemistry · San Diego, CA
- Associate Director/Director, FP&A · San Diego, CA
- Director, Compensation, Benefits and HR Systems · San Diego, CA
- IT Support Specialist · San Diego, CA
- Research Scientist II/Senior, Computational Chemistry · San Diego, CA
- Sr. Associate Scientist I / II – High Throughput Chemistry · San Diego, CA
Similar jobs
- Senior Business Systems Analyst, ANAPLAN · Nvidia · Santa Clara, CA
- Senior Business Technical Analyst · Centene · CA
- Business Systems Manager · University of Wisconsin-Green Bay · Madison, WI
- Senior Technical Field Consultant (CathWorks) - Orlando · Medtronic MiniMed · Orlando, FL
- Senior Technical Field Consultant (CathWorks) - Phoenix · Medtronic MiniMed · Phoenix, AZ
- Business Systems Analyst III · University of Wisconsin-Green Bay · Oshkosh, WI
Where San Diego, CA ranks
Where San Diego, CA placed in our monthly rankings, month by month. Each month stays online at its own address.
November 2026
- #1Cities hosting the most business conferences in the West Coast78 conferences · of 17
- #2Cities hosting the most human resources conferences6 conferences · of 10
- #3Best cities for life sciences and biotech jobs454 openings · of 41
- #3Best cities for aerospace and defense jobs377 openings · of 67
- #3Cities hosting the most legal services conferences7 conferences · of 17
- #3Cities hosting the most staffing & human capital conferences6 conferences · of 8
Rankings about engineering jobs
- Best cities for software and engineering jobs #1 San Francisco (3,412 openings)
- Best cities for engineering pay after cost of living #1 San Mateo ($216k)
- Most requested AI skills in engineering jobs #1 AI tools in daily work (6.1%)
- AI tools named most often in engineering jobs #1 Claude (1.7%)
- Employers with the most engineering jobs #1 Amazon (2,992 roles)
Pay compared with the market
This listing pays about $162,000 a year. Across 26 open sr manager listings that state pay, the middle half runs $163,000 to $218,000 and the median is $194,500. That is 17% below the median, below the middle half of those listings.
Listed pay is what employers advertise, not what people are paid.
How AI is used in this kind of work
Among computer systems analysts, AI is already used for some of the tasks. Measured exposure for computer systems analysts: 28% (some).
Share of this job’s tasks that AI is already used for at work, from real usage. It is not a forecast of job loss, and a low number means no use seen yet. Source: Anthropic Economic Index.
Skills this job asks for
Say which you have and which you want to build. We use it to match you to jobs like this one.
About the job
JOB SUMMARY
We are seeking an experienced and results-driven Sr Manager, Enterprise Business Systems to join our growing IT team. This role will oversee the implementation, configuration, maintenance, and support of business-critical applications across the organization, with primary focus on the systems that run our General & Administrative (G&A) functions: Finance and Accounting, People/HR, Legal and Compliance, and Facilities, IT Operations, and Business Operations.
The Sr. Manager, Enterprise Business Systems will collaborate with leaders across each G&A function to optimize workflows, troubleshoot system issues, and drive continuous improvement in business processes. This role ensures that business applications operate efficiently, securely, and meet the evolving strategic and tactical needs of the company.
This position will be based out of our San Diego Headquarters.
KEY RESPONSIBILITIES
- Apply deep working knowledge of enterprise software across the G&A landscape to implement, integrate, and maintain business applications supporting:
- Finance and Accounting (ERP, budget forecasting & tracking, procurement, invoicing & expenses),
- People/HR (HRIS, payroll, talent acquisition, learning management)
- Legal and Compliance (contract lifecycle management, e-signature, entity management)
- Facilities/Operations (service management, asset and space management).
- Ensure application security, role-based access controls, segregation of duties, and compliance with company policies across all G&A systems.
- Perform regular system updates, patches, and upgrades to maintain performance and security.
- Liaise with software vendors and service providers for application support and upgrades.
- Integrate business applications with other systems and third-party tools and assist in data migrations, imports, and exports between systems.
QUALIFICATIONS
- Bachelor’s degree in Information Technology, Computer Science, Business Administration, or a related field.
- 12 years IT experience, with 8+ years administering cross-functional business applications spanning multiple G&A functions, life sciences experience preferred
- Experience supporting financial processing and audit controls for Sarbanes-Oxley compliance, as well as the access, confidentiality, and retention requirements of HR and Legal systems.
- Working knowledge of data privacy and associated regulatory requirements such as GDPR, CCPA, HIPAA, and Transparency Reporting.
- Strong experience implementing, maintaining and improving Finance, Procurement, HR, Legal and Compliance systems such as NetSuite, Adaptive, Procurify, HRIS, Ashby ATS, DocuSign, and Ironclad preferred
- Experience managing SaaS vendor relationships, contracts, renewals, and license optimization across a portfolio of business applications.
- Experience in system implementation, data migration, or process automation.
- Excellent communication and collaboration abilities with strong analytical and problem-solving skills.
- Prior experience with IT service management, identity and access management (SSO, SCIM, provisioning), and corporate IT or facilities systems preferred
- Experience with reporting methodologies and business metrics preferred
- Project management experience or certifications (e.g., PMP, ITIL, Agile) preferred
ABOUT IAMBIC THERAPEUTICS Iambic Therapeutics (Nasdaq: IAM) is a technology and clinical-stage life sciences company headquartered in San Diego. By utilizing molecular superintelligence — integrating proprietary AI with automated, scalable chemistry and biology experimentation — our platform is designed to address the totality of drug discovery and development. At Iambic, we are building an engine that is designed to power the future of medicine. Learn more at iambic.ai http://iambic.ai.
MISSION & VALUES Our mission is to make better technology for better medicines. Three values guide how we work:
- Bold. We are courageous, take thoughtful risks, and approach challenges with tenacity.
- Innovative. We are creative and find new solutions that deliver impact.
- Collaborative. We respect one another and partner with integrity.
We value the range of perspectives our people bring, and we work to build an environment where every team member can contribute and grow.
PAY AND BENEFITS The pay range for this role is listed above. Actual pay depends on factors including experience, skills, and location. Eligible employees in the U.S. receive company-paid medical coverage, flexible spending accounts, voluntary life insurance, 401(k) matching and flexible time off. We are in a brand-new state-of-the art facility in beautiful San Diego with a community gym, dining, and easy access to great places to live and play.
EQUAL OPPORTUNITY Iambic is an equal opportunity employer. We consider all qualified applicants without regard to race, color, religion, sex, sexual orientation, gender identity or expression, national origin, ancestry, age, disability, medical condition, genetic information, marital status, veteran or military status, or any other characteristic protected by law.