Bioinformatics Programmer III

The Cardiovascular Genetics Center at University of California, San Francisco is seeking an experienced bioinfomatician to faciliate several lines of research that relate broadly to inherited forms of cardiovascular disease, regulation of gene expression in health and disease, and personalized genetic medicine. The incumbent will work closely with prinicpal investigators within the Genetic Center to design and implement analysis pipelines in several broad areas of computational biology including analysis of experimentally generated datasets in basic research, and analysis of patient-derived genomic data from UCSF patients as well as publicly available data repositories. The goal will be to make fundamental biological discoveries that can ultimately be translated to understanding, prevent, and treat heritable cardiovascular diseases. More specifically, the role involves developing and utilizing computational tools and systems to analyze and interpret biological or other research data. Utilizes and develops algorithms, computational techniques, and statistical methodologies. Helps in the design of new experiments. Implements end-user needs in database searching and integration. Maintains the computational infrastructure and tracks the flow of samples and information for large-scale studies. Provides web-based bioinformatics and access to public and proprietary databases.

The scope of work will include anayzing biological datasets generated experimentally including but not limited to bulk and single cell multiomics sequencing, epigenomics data including ChIP-Seq and CUT&RUN, and imaging data including spatial transcriptomics; overlapping experimental data with publicaly available genomic and expression datasets including UK Biobank, All of Us, Heart Cell Atlas, and similar datasets. There will also be analysis of genome sequencing data including whole exome- and whole genome sequencing to discern rare and common variants implicated in cardiovascular disease.The incumbent will also implement machine learning algorithms to analyze biological datasets. There will be frequent collaboration with bench scientists and clinicians in a highly collegial and stimulating scientific environment.

Required Qualifications

Bachelor's degree in biological science, computational / programming, or related area and / or equivalent experience / training

A minimum of 3 years of relevant work experience in bioinformatics or computational biology

Thorough knowledge of bioinformatics programming design, modification and implementation in relevant languages such as Python, R, and/or equivalent

Understanding of relational databases, web interfaces, and operating systems

Strong project management skills

Thorough knowledge of modern biology and applicable field of research

Communication skills to work with both technical and non-technical personnel in multiple fields of expertise and at various levels in the organization

Ability to communicate technical information in a clear and concise manner

Ability to interface with management on a regular basis

Self motivated, work independently or as part of a team, able to learn quickly, meet deadlines and demonstrate problem solving skills

Thorough knowledge of web, application and data security concepts and methods

Familiarity with cloud-based computing and high-performance computing environments

Proven expertise, as reflected in publication record, in analyzing high-throughput sequencing datasets, including RNA-sequencing, ATAC-sequencing, and chromatin occupancy studies

Thorough In-depth knowledge of genomic databases, tools, and statistical frameworks

Preferred Qualifications

PhD in Bioinformatics or a closely related field

About UCSF

The University of California, San Francisco (UCSF) is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care. It is the only campus in the 10-campus UC system dedicated exclusively to the health sciences. We bring together the world’s leading experts in nearly every area of health. We are home to five Nobel laureates who have advanced the understanding of cancer, neurodegenerative diseases, aging and stem cells.

Pride Values

UCSF is a diverse community made of people with many skills and talents. We seek candidates whose work experience or community service has prepared them to contribute to our commitment to professionalism, respect, integrity, diversity and excellence – also known as our PRIDE values .

In addition to our PRIDE values, UCSF is committed to equity – both in how we deliver care as well as our workforce. We are committed to building a broadly diverse community, nurturing a culture that is welcoming and supportive, and engaging diverse ideas for the provision of culturally competent education, discovery, and patient care. Additional information about UCSF is available here .

Join us to find a rewarding career contributing to improving healthcare worldwide.

Equal Employment Opportunity

The University of California is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected status under state or federal law.

Salary Information

The final salary and offer components are subject to additional approvals based on UC policy.

Your placement within the salary range is dependent on a number of factors including your work experience and internal equity within this position classification at UCSF. For positions that are represented by a labor union, placement within the salary range will be guided by the rules in the collective bargaining agreement.

To learn more about the benefits of working at UCSF, including total compensation, please visit: https://ucnet.universityofcalifornia.edu/compensation-and-benefits/index.html