Senior Program Manager – Security and Performance
InterSystems
Boston, MA · $147k–$185k a day · Posted January 22, 2026
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Where Boston, MA ranks
Where Boston, MA placed in our monthly rankings, month by month. Each month stays online at its own address.
November 2026
- #1Best cities for life sciences and biotech jobs793 openings · of 41
- #1Cities with the most jobs that do not need a four-year degree in New England390 jobs · of 14
- #1Best cities for AI-skill jobs in New England21% · of 28
- #1Best cities for software and engineering jobs in New England910 openings · of 24
- #1Best all-round cities for mid-career professionals in the Northeast71 / 100 · of 26
- #1Best all-round cities for mid-career professionals in New England71 / 100 · of 11
Rankings about security jobs
- Best cities for security jobs #1 San Francisco (316 openings)
- Best cities for security pay after cost of living #1 San Mateo ($241k)
- Most requested AI skills in security jobs #1 AI tools in daily work (10.8%)
- Employers with the most security jobs #1 Amazon (318 roles)
Pay compared with the market
This listing does not state pay. Across 104 open senior program manager listings that state pay, the middle half runs $133,500 to $179,000 and the median is $153,000.
Listed pay is what employers advertise, not what people are paid.
Senior Program Manager salaries by state · Check your own pay
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About the job
InterSystems is a global leader in healthcare data management and interoperability, providing mission-critical technology that powers hospitals, health systems, and national infrastructures worldwide. Our products underpin trusted healthcare and financial systems where performance, availability, and security are non-negotiable.
As a Senior Program Manager, you lead large-scale, complex, cross-functional initiatives across product, engineering, cloud, and AI. You operate across organizational boundaries, translating objectives aligned to corporate strategy into coordinated, measurable outcomes. You support and operationalize the security strategy across the portfolio, ensuring effective execution through structured programs.
Security and performance are horizontal capabilities across our stack. You partner with product, engineering, and architecture to maintain consistent execution across the portfolio.
Key Characteristics
Thrives in high ambiguity, competing priorities
Owns outcomes at a program level
Connects strategy to execution (systems thinker)
Influences without authority
Execution-focused; manages complexity
Communicates clearly across technical and business audiences
Key Responsibilities
Program Strategy, Execution & Delivery
Execute against existing program direction and strategic priorities, incorporating security and performance, and influencing future prioritization and execution
Translate program strategy into execution plans across multiple teams and projects
Lead concurrent projects to deliver program objectives
Coordinate execution with program managers across cloud, database, interoperability, HealthShare, and AI-enabled systems
Align scope, priorities, and dependencies to enable delivery
Cross-Functional Leadership & Stakeholder Management
Orchestrate work across product, engineering, architecture, compliance, and operations
Serve as integration point for dependencies, timelines, and deliverables
Manage senior stakeholders, including executive engagement
Communicate progress, risks, and decisions to support leadership action
Run structured updates and program reviews to maintain alignment
Program Performance, Health & Continuous Improvement
Monitor program performance and health against established KPIs, objectives, and milestones; contribute to KPI refinement
Manage risks, issues, and dependencies; escalate when needed
Maintain clear program visibility and enforce accountability
Improve execution, coordination, and operational effectiveness
Qualifications
Bachelor’s degree in Computer Science, Business, Engineering, or related field; advanced degree preferred
10+ years leading large-scale, complex, cross-functional programs
Strong fundamentals in planning, scheduling, dependency and risk management
Experience managing performance to KPIs and driving accountability
Experience in cloud, healthcare, or enterprise technology environments preferred
Proven ability to influence senior stakeholders without direct authority
Strong communication and leadership skills
PMP or equivalent certification a plus
Experience using AI-assisted tools (e.g. copilots, summarisation tools, or chatbots) with an ability to critically evaluate and verify AI-generated outputs
Demonstrated ability to learn, evaluate, adapt to, propose and implement AI-augmented workflows in order to continually enhance your own, and the team’s productivity
We are an equal-opportunity employer and do not discriminate because of race, color, religion, sex, national origin, ancestry, marital status, veteran status, age, disability, sexual orientation or gender identity or expression or any other legally protected category. InterSystems is an E-Verify Employer in the United States.
InterSystems is providing a current good faith estimate of the anticipated base salary range for this position depending on a variety of factors including experience, education, skills, and performance.
Other compensation may include a discretionary annual variable target incentive.
The company also provides generous employee benefits including:
Medical, vision, and dental insurance
Short-term and long-term disability, and life insurance
401(k) Profit Sharing Contribution
Paid Time Off and Holidays
Parental Leave
Tuition reimbursement
The estimated base compensation range for this role is: $147,000 — $185,000 USD
About InterSystems
InterSystems, a creative data technology provider, delivers a unified foundation for next-generation applications for healthcare, finance, manufacturing, and supply chain customers in more than 80 countries. Our data platforms solve interoperability, speed, and scalability problems for large organizations around the globe to unlock the power of data and allow people to perceive data in imaginative ways. Established in 1978, InterSystems is committed to excellence through its 24×7 support for customers and partners around the world. Privately held and headquartered in Boston, Massachusetts, InterSystems has 38 offices in 28 countries worldwide. For more information, please visit InterSystems.com .
AI Disclaimer
InterSystems may use AI tools for its internal operations including administrative tasks during recruitment (e.g., organizing candidate information). InterSystems’ approach to AI is guided by the InterSystems Responsible AI Guidelines . AI is not used to make or influence hiring decisions. All decisions are made by InterSystems employees.
Candidates may use AI for CV or interview preparation, provided materials are truthful and reflect their own experience. AI tools and third-party transcription services must not be used during interviews or assessments.
Please note that the use of wearable technology, including any AI-related tools or other technology-connected devices (such as META or Google smart glasses and/or wearables, and/or any similar devices), is strictly prohibited during the interview and screening process with InterSystems. Any applicant who requires a wearable device or any type of technology support during the interview process as a reasonable accommodation under the ADA or applicable state or country laws and regulations must contact the InterSystems Human Resources Department prior to attending or participating in any interview or screening process.