Chief Clinical Innovation Officer
Ascension Seton
Remote · St Louis, MO · Posted November 3, 2026
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Where St Louis, MO ranks
Where St Louis, MO placed in our monthly rankings, month by month. Each month stays online at its own address.
November 2026
- #9Best all-round cities for new graduates in the Midwest52 / 100 · of 20
- #9Cities hosting the most business conferences in the Midwest8 conferences · of 12
- #9Cities hosting the most legal services conferences4 conferences · of 17
- #11Best cities for government pay after cost of living$123k · of 18
- #11Best cities for entry-level jobs that want AI skills in the Midwest4% · of 52
- #12Best all-round cities for remote workers in the Midwest42 / 100 · of 20
Rankings about clinical jobs
- Best cities for clinical jobs #1 New York (202 openings)
- Employers with the most clinical jobs #1 Veterans Health Administration (215 roles)
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AI use among chief executives is little observed so far. Measured exposure for chief executives: 3% (little observed).
Share of this job’s tasks that AI is already used for at work, from real usage. It is not a forecast of job loss, and a low number means no use seen yet. Source: Anthropic Economic Index.
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About the job
Location: Remote with travel
Salary: $313,891 - $431,600 annual. The expected compensation range for this position is from the minimum to the midpoint of the pay grade. Actual compensation will be based on factors such as experience, education, and organizational fit. This position is eligible for participation in the annual bonus program.
The Chief Clinical Innovation Officer provides strategic leadership in the design, development, implementation, and optimization of clinical practices across the organization. This role advances clinical transformation by establishing evidence-based care standards, enabling technology-integrated clinical workflows, and driving sustainable changes in care delivery to improve quality, safety, health outcomes, and patient and clinician experiences.
Working in close partnership with enterprise, market, and clinical leadership, this executive translates organizational clinical priorities into scalable strategies and operational solutions. The Vice President champions clinical innovation, accelerates adoption of technology-enabled care models, and drives measurable improvements aligned with the quadruple aim and Ascension's mission.
Clinical Strategy & Transformation: Develops and advances enterprise clinical practice strategies that align with organizational priorities, improve care delivery, and drive measurable improvements in quality, safety, clinical outcomes, and patient and clinician experiences.
Clinical Practice Optimization: Partners with clinical leaders, physicians, clinicians, and operational stakeholders to establish, standardize, and optimize evidence-based clinical practices, care standards, and workflows across the organization.
Technology-Enabled Care Delivery: Collaborates with Ascension Technologies, Studio leadership, and clinical and operational partners to evaluate, implement, and optimize technology-enabled solutions that advance clinical practice, improve workflow efficiency, and support high-reliability healthcare delivery.
Virtual Care Innovation: Partners with virtual care leadership to develop and operationalize innovative care models, clinical use cases, and workflows that expand access, enhance care coordination, and improve the delivery of care.
Change Leadership & Adoption: Leads enterprise alignment, stakeholder engagement, and change management strategies to drive adoption and sustained integration of clinical practice improvements across diverse clinical environments.
Clinical Experience & Workforce Effectiveness: Identifies barriers and emerging opportunities affecting clinical practice and develops strategies that improve care team effectiveness, reduce operational friction, and enhance the clinician experience.
Performance & Outcomes Management: Establishes performance measures, monitors key clinical and operational indicators, and evaluates the effectiveness of clinical redesign initiatives to ensure measurable, sustainable outcomes.
Executive Partnership & Influence: Advises and collaborates with senior enterprise, market, and clinical leaders to translate strategic priorities into actionable clinical initiatives and advance organizational performance.
Financial & Resource Stewardship: Partners in the development and oversight of operating budgets, financial targets, workforce plans, and resources necessary to execute clinical practice strategies.
Execution & Accountability: Establishes short- and long-term objectives, monitors progress against strategic plans and budgets, and ensures initiatives deliver intended clinical, operational, and financial results.
Licensure / Certification / Registration
Required Credential(s): Physician MD/DO obtained prior to hire date or job transfer date.
Education
Associate's degree/Bachelor's degree with 7 years of applicable cumulative job specific experience required, with 4 of those years being in leadership/management.
Additional Preferences:
Graduate of an accredited medical school.
Additional graduate-level education in healthcare administration, business administration, public health, or a related discipline preferred.
Significant progressive clinical and physician leadership experience within a complex healthcare environment.
Demonstrated experience leading clinical transformation, practice redesign, and enterprise-wide improvement initiatives.
Experience developing and implementing technology-enabled clinical workflows and innovative care delivery models.
Demonstrated ability to influence senior executives, physicians, clinical leaders, and operational stakeholders across a matrixed organization.
Experience driving measurable improvements in clinical quality, patient safety, operational performance, and clinician experience.
Demonstrated financial acumen and experience managing budgets, resources, and performance outcomes.
Ascension is a leading nonprofit Catholic health system with a culture and associate experience grounded in service, growth, care and connection. We empower our 99,000+ associates to bring their skills and expertise every day to reimagining healthcare, together. Recognized as one of the Best 150+ Places to Work in Healthcare and a Military-Friendly Gold Employer, you'll find an inclusive and supportive environment where your contributions truly matter.
Equal employment opportunity employer
Ascension provides Equal Employment Opportunities (EEO) to all associates and applicants for employment without regard to race, color, religion, sex/gender, sexual orientation, gender identity or expression, pregnancy, childbirth, and related medical conditions, lactation, breastfeeding, national origin, citizenship, age, disability, genetic information, veteran status, marital status, all as defined by applicable law, and any other legally protected status or characteristic in accordance with applicable federal, state and local laws. For further information, view the EEO Know Your Rights (English) poster or EEO Know Your Rights (Spanish) poster.
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