Senior Director of Nursing Practice
Ascension Seton
Remote · Saint Louis, MO · Posted November 9, 2026
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November 2026
- #9Best all-round cities for new graduates in the Midwest52 / 100 · of 20
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Rankings about clinical jobs
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About the job
Location: Remote with up to 50% Travel
Department/Specialty: Nurse Education
Schedule: Full-time, Days
Eligible for annual bonus incentive #LI-Remote
Drives nursing priorities aligned with the Ascension Strategic Plan.
Develops, implements, and evaluates evidence-based nursing practice initiatives and nursing standards across the continuum of care (including ambulatory), with a focus on improving patient outcomes and nurse engagement.
Evaluates outcome metrics, process metrics, and nurse-sensitive indicators to construct scalable, data-driven plans for improvement.
Boundary span and collaborate with stakeholders, including clinical, operations, system, market, and local level leadership, to achieve organizational goals amenable to nursing practice.
Leads efforts to advance a professional practice ecosystem, ensure high performance in nurse sensitive indicators, and support data-driven improvements at all organizational levels.
Licensure / Certification / Registration
Required Credential(s): Certified Registered Nurse obtained prior to hire date or job transfer date.
Education
Bachelor's degree in nursing or diploma from an accredited school/college of nursing required. Master's degree or combination of Bachelor's degree and experience preferred.
Work Experience
5 years of experience required. 10 years of experience preferred. 2 years of leadership or management experience required. 5 years of leadership or management experience preferred.
Additional Preferences
Doctorate preferred.
Experience in nursing leadership to support a high-impact nursing operations framework.
Proven success leading evidence-based nursing and patient safety initiatives.
Proven system-level or multi-site healthcare leadership experience.
Ascension is a leading nonprofit Catholic health system with a culture and associate experience grounded in service, growth, care and connection. We empower our 99,000+ associates to bring their skills and expertise every day to reimagining healthcare, together. Recognized as one of the Best 150+ Places to Work in Healthcare and a Military-Friendly Gold Employer, you'll find an inclusive and supportive environment where your contributions truly matter.
Equal employment opportunity employer
Ascension provides Equal Employment Opportunities (EEO) to all associates and applicants for employment without regard to race, color, religion, sex/gender, sexual orientation, gender identity or expression, pregnancy, childbirth, and related medical conditions, lactation, breastfeeding, national origin, citizenship, age, disability, genetic information, veteran status, marital status, all as defined by applicable law, and any other legally protected status or characteristic in accordance with applicable federal, state and local laws. For further information, view the EEO Know Your Rights (English) poster or EEO Know Your Rights (Spanish) poster.
Fraud prevention notice
Prospective applicants should be vigilant against fraudulent job offers and interview requests. Scammers may use sophisticated tactics to impersonate Ascension employees. To ensure your safety, please remember: Ascension will never ask for payment or to provide banking or financial information as part of the job application or hiring process, our legitimate email communications will always come from an @ascension.org email address; do not trust other domains, and an official offer will only be extended to candidates who have completed a job application through our authorized applicant tracking system.
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